Role of IDO1 and GCN2–mTOR Signaling in CD8⁺ T-Cell Dysfunction in Breast Cancer
Breast cancer growth and development are determined by the interactions between malignant epithelial cells, immune cells, and metabolic processes in the tumor microenvironment. Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the conversion of the essential amino acid tryptophan to kynurenine, which may suppress antitumo...