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Author

Pritha Dasgupta

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Open access Aug 2026

FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators

VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully understood. Here, we screen cofactors and identi...

Pritha Dasgupta, Ian R. Kelsall, Gaurav Anand et al. · 0 citations
Open access Sep 2026

Engineering Glucose-Tolerant Variants by Probing Residues Lining the Active Site of a Fungal β-Glucosidase.

The hydrolytic breakdown of cellobiose into glucose, catalyzed by β-glucosidases, is the last and rate-limiting step in cellulose saccharification for producing fermentable glucose in the bioethanol industry. This limitation arises because β-glucosidase activity is inhibited by factors such as temperature, pH, and gluc...

Barnava Banerjee, Dipayan Chatterjee, Pritha Dasgupta et al. · 0 citations

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