Author

Prathap Nagaraja Shastri

2 papers indexed here

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Review Open access Aug 2026

Industry Perspective on Translational and Clinical Pharmacology Aspects of Viral-based Gene Therapies and Vaccines—Key Considerations and Learnings From Approved Products

Viral-based gene therapies and vaccines represent a rapidly evolving modality for treating a wide range of diseases. However, these novel modalities pose novel and complex challenges for translational PK/PD scientists and clinical pharmacologists during preclinical and clinical development. To support accelerated devel...

H. Mody, Jatin Narula, Prathap Nagaraja Shastri et al. · AAPS Journal · 0 citations

#protein folding Open access Oct 2026

Bispecific antibodies that engage pIgR enrich in mucosa in cynomolgus monkeys.

It is shown that pIgR-targeted bispecific antibodies rapidly deplete from serum, while enriching 5-10-fold in bronchoalveolar lavage fluid compared to normal IgG antibodies, which support the use of anti-pIgR bispecific antibodies to treat diseases requiring targeting in mucosal areas.

Kelsie Marks, Nirav Shah, L. Phạm et al. · mAbs · 0 citations