Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains low-throughput, labor-intensive, and dependent on randomized libraries or non-human display systems, limiting functional selection in mammalian...
Lin Zhao, Anuoluwapo A. Mattix, Aastha Pal et al.· bioRxiv· 0 citations
Four recently released ES and ER prediction models are benchmarked and it is suggested that interaction-aware representations from full biomolecular complexes may provide a promising basis for enzyme prioritization.
Elizabeth H. Mahood, N. Komorníková, Tom'avs Pluskal et al.· 0 citations
EvoMax is established as an integrated strategy for engineering compact eukaryotic Fz2 genome editors and FanzMAX v3-hLa is identified as a high-efficiency programmable nuclease for mammalian genome editing.
Shijie Wan, J. Gold, Pranay Vure et al.· Nature Biotechnology· 1 citation
PeptiVerse is a unified platform that leverages large foundation models to predict diverse peptide developability properties from both amino acid sequences and SMILES representations, enabling accessible, scalable analysis for peptide drug design.
