Despite advances in traditional lipid-lowering, antithrombotic, and antihypertensive therapies, cardiovascular disease remains the leading cause of mortality worldwide. Small interfering RNA (siRNA) therapeutics harness the endogenous RNA interference pathway to degrade target messenger RNA, thereby reducing synthesis...
K. Paruchuri, Jaiden I. Busso, Pradeep Natarajan· Annual Review of Pharmacolog...· 0 citations
Background: Hypertensive disorders of pregnancy (HDP) affect over 10% of pregnancies worldwide, but their association with cardiovascular-kidney-metabolic (CKM) syndrome remains unexplored. Methods: The present study included parous UK Biobank participants. The primary exposure was HDP history. CKM syndrome was categor...
D. Ezzat, Maria A. Pabon, Lin-Ke Li et al.· HYPERTENSION· 0 citations
AIM
Coronary artery disease (CAD) remains the leading cause of morbidity and mortality globally. Polygenic Risk Scores (PRS) have been trained against major adverse cardiovascular outcomes (MACE) in large cohorts. Few studies have examined the effectiveness of these CAD MACE PRS tools in detecting individuals with subc...
M. Gray, D. Strbenac, Daniel Brieger et al.· European Journal of Preventi...· 0 citations
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