Open access
Aug 2026
P-KNN: joint calibration of multiple pathogenicity prediction tools streamlines variant classification
Pathogenicity K-Nearest Neighbors (P-KNN) provides robust joint calibration for any set of pathogenicity prediction tools, thereby alleviating the constraint of pre-committing to a single predictor while enhancing statistical rigor and diagnostic yield.
Po-Yu Lin, N. Brandes
· Genetics in Medicine · 0 citations