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Po-Yu Liang

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Aug 2026

A CAR-T Tonic Signaling Code Predicts Anti-Tumor Efficacy in Diffuse Midline Glioma.

BACKGROUND Diffuse middle glioma (DMG or DIPG) is a fatal pediatric brain tumor. Although chimeric antigen receptor (CAR) T-cell therapy shows promise, clinical outcomes remain inconsistent due to premature exhaustion, underscoring a critical need to improve CAR-T persistence. A major barrier to CAR-T efficacy is antig...

Bing Deng, Xiaowen Zhong, Da-Zhuan Xin et al. · 0 citations
Book Open access Jun 2026

PepEDiff: Out-of-Distribution Sampling Peptide Binder Design via Protein Embedding Diffusion

PepEDiff is presented, a novel peptide binder generator that designs binding sequences given a receptor protein and the target pocket residues that outperforms state-of-the-art approaches across benchmark tests and in the TIGIT case study, demonstrating its potential as a general, structure-free framework for zero-shot...

Po-Yu Liang, Tibo Duran, Jun Bai · 1 citation

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