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Po-Ming Wu

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Open access Aug 2026

Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease.

A previously unrecognized modulatory role of wt-C9orf72 in regulating mHTT aggregation in experimental HD models is identified and a novel wt-C9orf72-Stat1-Isg15 axis is identified, providing new insights into wt-C9orf72-associated protein homeostasis.

Siew Chin Chan, Chih-Wei Tung, Chih-Yi Chang et al. · 0 citations

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