Author

Pipob Suwanchaikasem

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Open access Jan 2026

Neuroprotective Effects of Huperzine B and Huperzia carinata Extract Against MPP+‐Induced Oxidative Stress in SH‐SY5Y Cells

Parkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance. Huperzine B (HupB), an alkaloid derived from Huperzia species, has demonstrated antioxidant and acetylcholinesterase‐inhibitory activity; however, its effects in toxin‐ind...

Kittikun Viwatpinyo, Poommaree Namchaiw, Pipob Suwanchaikasem et al. · Advances in pharmacological... · 0 citations

Open access Sep 2026

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

Aging progressively challenges neuronal proteostasis, redox homeostasis, and metabolism, yet the molecular changes that precede functional decline remain poorly understood. Endoplasmic reticulum oxidoreductin 1 (ERO1), a key regulator of oxidative protein folding, links endoplasmic reticulum (ER) proteostasis with cell...

L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Fusion Partner and ER-Retention Signal Are Associated with Distinct Host Proteomic and Metabolic Responses During Interleukin-15 Production in Nicotiana benthamiana

Plant molecular farming has emerged as a promising platform to produce recombinant biopharmaceuticals. The expression of foreign proteins changes the host proteome and metabolome, and these changes might have an effect on the accumulation of recombinant proteins. In this study, we investigated how fusion partners and E...

A. Savinova, Pipob Suwanchaikasem, Balamurugan Shanmugaraj et al. · Plants · 0 citations

Open access Jul 2026

Comparative proteomics and metabolomics reveals distinct host protein quality control and metabolic signatures during recombinant IL1-His and IL15-His expression in Nicotiana benthamiana

Findings underscore that the characteristics of the target protein and its interaction with the host's physiology could influence the yield of the recombinant protein production in plants.

A. Savinova, Theerakarn Srisangsung, Pipob Suwanchaikasem et al. · PLoS ONE · 0 citations