Author

Pingping Zeng

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Open access Oct 2026

IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma.

An IGF2BP1/MYCN-PAICS-CHK1 axis that drives aggressive neuroblastoma phenotypes and constitutes an actionable vulnerability for therapeutic intervention is identified.

Jia-Xu Liu, Ying-Zhe Fang, Rong-Rong Fan et al. · Proceedings of the National... · 0 citations

Jul 2026

Selective and Potent First-in-Class CRBN-Dependent Molecular Glue Degraders of WW Domain-Binding Protein 4.

Targeted protein degradation via molecular glues represents a powerful modality for modulating "undruggable" proteins. Herein, through proteomic profiling of a CRBN-binding library and rigorous structure-activity relationship (SAR) refinement, we report the discovery of dWBP4-1: a first-in-class, highly selective, CRBN...

Yu-Hang Liu, Lu Chen, Bo Peng et al. · Angewandte Chemie · 0 citations