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Review Open access Sep 2026

ILC plasticity in intestinal immune barrier remodeling: current evidence and therapeutic implications for inflammatory bowel disease

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic gastrointestinal inflammatory diseases characterized by persistent mucosal inflammation and intestinal immune barrier dysfunction. Innate lymphoid cells (ILCs) are key regulators of mucosal immunity;...

Zi-Qing Zhou, Ping Ling, Jin-Xin Wang et al. · 0 citations
Review Open access Sep 2026

The shifting balance: innate lymphoid cell plasticity in chronic gut diseases

Innate lymphoid cells (ILCs), as core components of innate immunity, coordinate mucosal immune defense and homeostasis through their functional plasticity. They exhibit functional diversity in the intestine and display a complex dual role in intestinal diseases, which is closely associated with their phenotypic transfo...

Ping Ling, Jin-Tao Fang, Jin-Xin Wang et al. · 0 citations

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