Dual-Activating Pyroptosis and cGAS-STING Pathway for Immuno-Photodynamic Therapy Based on a Thermally Activated Delayed Fluorescence Photosensitizer.
Both in vitro and in vivo studies demonstrate that TA2O effectively eradicates tumor cells, promotes dendritic cell maturation, facilitates cytotoxic T lymphocyte infiltration, and induces a marked M2-to-M1 macrophage polarization, effectively promoting immune infiltration and inflammatory remodeling of the tumor micro...