Open access
Sep 2026
Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms
Abstract Schizophrenia (SCZ) and systemic lupus erythematosus (SLE) exhibit epidemiological overlap, suggesting shared genetic underpinnings. Using the largest SLE genome-wide association study (GWAS) to date, we identified a significant genetic correlation between SCZ and SLE (rg = 0.25, p = 9.0 × 10−4). Cross-trait a...
Chen Gong, N. Dand, A. W. Butler et al.
· Human Molecular Genetics · 0 citations