Open access
Aug 2026
Label Noise Limits TCR-pMHC Specificity Prediction: Improved Performance Through AlphaFold3-Based Structural Modeling and Data Denoising
It is shown that combining structural modeling with label denoising substantially improves TCR-pMHC specificity prediction, making such approaches an attractive complement to current sequence-based approaches for refining TCR target selection.
Pilar Ballesteros-Cuartero, J. Lund, Morten Nielsen
· bioRxiv · 1 citation
· ⚡1