Author

Pi-Wu Li

2 papers indexed here

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Sep 2026

Engineering a thermostable MHET-active esterase through active-site compaction for efficient dual-enzyme PET depolymerization.

Efficient enzymatic recycling of polyethylene terephthalate (PET) is frequently hindered by the accumulation of mono-(2-hydroxyethyl) terephthalate (MHET), a soluble intermediate that competitively suppresses PET hydrolase activity. Although MHET-hydrolysing enzymes can overcome this limitation, these enzymes often exh...

Li-Na Qiu, Jie Zhang, Yan-Zi Sun et al. · Bioorganic chemistry (Print) · 0 citations

Review Open access Jul 2026

The disorazole family of potent anticancer agents: structures, bioactivity, total synthesis, and heterologous biosynthesis.

This review articulates a paradigm shift in disorazole research: from confronting the extreme challenge of total chemical synthesis towards harnessing programmable biosynthetic engineering (F & Z), and highlights how key technologies have revolutionized the production and diversification of these molecules.

Guoan Fu, He Li, Ruijuan Li et al. · Journal of Advanced Research · 0 citations