Author

Philipp Borchert

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Open access Aug 2026

Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants

Modified AAV capsids derived from the established AAV2 with HSPG-tropism knockdown and two less-characterized, tropism-reduced AAV9 variants were engineered and EGFR-dependent transduction was targeted, with AAV9-affibody variants surpassing AAV9 wild-type.

Claire Rothschild-Gronau, Philipp Borchert, M. Radukic et al. · Scientific Reports · 0 citations