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Author

Petro O. Borysko

2 papers indexed here

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Open access Sep 2026

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

An efficient and common strategy for the generation of pharmaceutically relevant functionalized molecules based on the diversity‐ and lead‐oriented synthesis (DOS/LOS)‐like concepts is presented. The approach is implemented for the case of functionalized sp3‐enriched derivatives of isoxazole and isoxazoline. The key ch...

B. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova et al. · 0 citations
Review Open access Aug 2026

Structure-activity relationship of drug-derived molecules containing spirocyclic azetidine or 2,4-methanopyrrolidine moiety

Local structural modification of approved drugs is a productive route in medicinal chemistry. If the parent molecule has already undergone pharmacological validation, the replacement of a single moiety can alter its solubility, metabolic stability, or some other properties, without altering the remaining essential char...

Petro O. Borysko · 0 citations

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