Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems
Cyclic nucleotide second messengers are used in all domains of life to amplify viral infection signals and activate cellular defences. In prokaryotes, CBASS (cyclic nucleotide-based antiphage signalling system) and type III CRISPR-Cas systems generate a range of cyclic nucleotides which bind and allosterically activate...
S. Grüschow, Peter Wotherspoon, Emma Hilton-Balfe et al.
· PLoS Biology · 1 citation
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