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Author

Peter S. Shen

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Review Open access Sep 2026

Viral control of translation: rise of the ribosome

ABSTRACT Viruses have evolved a myriad of strategies to manipulate their host’s protein synthesis machinery, studies of which uncovered many founding principles of translational control. Decades of research have established our now-extensive understanding of how these pathogens target the array of translation factors t...

Peter S. Shen, Derek Walsh · 0 citations
Open access Aug 2026

C. elegans Dicer stacks with the RIG-I-like receptor DRH-1 to cleave dsRNA

In prior studies we showed that the nematode ancestor of Dicer’s helicase domain had minimal ATP hydrolysis, translocation and dsRNA binding activity, and in extant C. elegans the RIG-I like receptor (RLR) DRH-1, and the dsRNA binding protein RDE-4, were co-opted to provide these activities. Here we report cleavage-com...

Claudia D. Consalvo, Parker J. Nichols, E. Boyle et al. · 0 citations

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