Author

Peter S Nelson

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Open access Aug 2026

Combined BET bromodomain and DNA methyltransferase inhibition targets critical survival pathways in transdifferentiated prostate cancer

Combined BET bromodomain and DNA methyltransferase (DNMT) inhibition was more effective than single-agent treatment in suppressing growth of TP53/RB1-loss models exhibiting a stem-like or NEPC program.

W. Storck, Diana Flores, A. Kumaraswamy et al. · JCI Insight · 0 citations

Review Open access 2026

Cellular plasticity and tumor ecosystem dynamics in prostate cancer: insights from single-cell and spatial transcriptomics.

Recent discoveries from single-cell and spatial analyses are summarized, their implications for biomarker development and treatment stratification are discussed, and ongoing technical challenges are outlined, including standardization, reproducibility, and clinical scalability.

R. Watanabe, T. Chu, N. Miura et al. · American journal of clinical... · 2 citations