Author

Peter Rupprecht

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Open access Sep 2026

PURELIGHT: a quantitative photon-counting framework unifying intensity and lifetime imaging at video rate across detector technologies

Quantitative fluorescence microscopy requires photon-efficiency, speed and accurate intensity and lifetime measurements. Time-correlated single-photon counting (TCSPC) simultaneously captures intensity and lifetime, but photon pile-up distorts both signals at high count rates, preventing fast acquisitions. Existing cor...

Felipe Velasquez Moros, Dorian Amiet, Daria Skwarzynska et al. · bioRxiv · 0 citations

Open access Sep 2026

Representational learning by optimization of neural manifolds in an olfactory memory network.

Cognition relies on internal representations of relevant information that are organized by constraining population dynamics to activity subspaces referred to as neural manifolds. Here, to examine how manifold geometry is modified by experience, we trained juvenile and adult zebrafish in an odor discrimination task and...

Bo Hu, Nesibe Z. Temiz, Chi-Ning Chou et al. · Nature Neuroscience · 0 citations