Open access
Oct 2026
DNA2 nuclease inactivation induces DNA damage through a potential protein trapping mechanism.
It is found that expression of DNA2 nuclease-dead alleles exert dominant effects on fitness and DNA damage repair that are dependent on its helicase and RPA binding activities, suggesting a protein trapping mechanism, perhaps associated with extensive helicase activity.
Katherine E. Baillie, Si-Jie Zhang, Jian Qin et al.
· DNA Repair · 0 citations