Author

Pengfei Su

3 papers indexed here

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Review Aug 2026

Targeting immunosuppressive tumor microenvironment to combat immunotherapy resistance: From mechanistic insights to therapeutic strategies.

With advances in deciphering the intricate interplay between tumors and the immune system, tumor immunotherapy has flourished significantly and has revolutionized conventional tumor therapies, owing to its durable immunological memory and favorable safety profile. Nevertheless, immunotherapy is not currently beneficial...

Pengfei Su, Ying-Jing Zhang, T. Yu et al. · International Immunopharmaco... · 0 citations

Aug 2026

YAP1-Driven PLCβ1 Impairs MHC-I Antigen Presentation and Limits Anti-Tumor Immunity in Gastrointestinal Cancer.

Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet its efficacy in gastrointestinal malignancies is often limited by an immunosuppressive tumor microenvironment. In this study, we identified phospholipase C beta 1 (PLCβ1) as a central driver of pathogenesis and ICB resistance in gastrointestinal...

Yingjing Zhang, Pengfei Su, Tian Yu et al. · Cancer Research · 0 citations

Open access Jul 2026

FADS1-mediated Efferocytosis in Tumor-Associated Macrophages Shapes an Immunosuppressive Microenvironment in Gastric Cancer.

Tumor-associated macrophages (TAMs) play a central role in tumor progression and therapeutic resistance. Alterations in unsaturated fatty acids (UFAs) metabolism are known to contribute to the immunosuppressive properties of TAMs. However, the complex regulatory relationship between UFAs metabolism and TAMs during gast...

Yingjing Zhang, Rongyuan Wei, Pengfei Su et al. · Cellular and Molecular Life... · 0 citations