A single-nucleus transcriptomic atlas spanning the human lifespan is used to show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in la...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 4 citations
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 6 citations
It is shown that the adult olfactory epithelium recapitulates key transcriptional and regulatory programs of cortical neurogenesis, providing an accessible model for studying psychiatric disease-associated neurodevelopment.
Liting Song, J. Fullard, Claire Coleman et al.· Nature Communications· 0 citations
Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.
