Fluorinated phosphate-modified micelles for bone-targeted oxygen delivery enabling enhanced photodynamic therapy of osteomyelitis.
Osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most challenging bone infections to treat clinically. Biofilm formation and the typical hypoxic microenvironment of infected bone tissue jointly undermine the efficacy of conventional antibiotic therapy and emerging photodynam...