Open access
Mar 2026
ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing
This work demonstrates that the UT3 domain of Ufd1 interacts simultaneously with two Lys48-linked ubiquitins and unfolds one of the ubiquitins by binding its C-termianl β-strand into a cleft and establishes a linkage-specific recognition that involves ubiquitin unfolding.
Yan-Zhu Wang, Zhi-Min Zhang, Wei He et al.
· bioRxiv · 1 citation