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Peng-Yu Wang

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Open access Mar 2026

ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing

This work demonstrates that the UT3 domain of Ufd1 interacts simultaneously with two Lys48-linked ubiquitins and unfolds one of the ubiquitins by binding its C-termianl β-strand into a cleft and establishes a linkage-specific recognition that involves ubiquitin unfolding.

Yan-Zhu Wang, Zhi-Min Zhang, Wei He et al. · 1 citation

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