Peng-Yang Gu

Single-cell RNA-seq and machine learning identify HMGN2 as a lactylation-associated hub gene in heart failure

Heart failure (HF) is a diverse condition characterized by dysregulated lactate metabolism and histone lactylation, which may contribute to maladaptive cardiac remodeling. However, the cell type-specific mechanisms underlying these processes remain poorly understood. To address this gap, we integrated single-cell RNA s...