Peng-Wei Hu

scASprofiler: profiling single-cell RNA splicing with a deep convolutional generative network

Abstract Single-cell RNA sequencing (scRNA-seq) enables the investigation of alternative splicing (AS) at cellular resolution. However, the analysis of AS in scRNA-seq data is constrained by sparse splice-junction coverage, a consequence of low sequencing depth per cell. This limitation is particularly pronounced in 3′...