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Sep 2026

Biotin‐Engineered Phenothiazine Photosensitizer Boosts Type I Photodynamic Therapy via Singlet‐Excited‐State Electron Transfer

Type II‐dominant photosensitizers often suffer from reduced photodynamic efficacy under tumor hypoxia. We report a biotin‐modified phenothiazine photosensitizer termed DHU‐Blue‐7, which converts type II methylene blue (MB)‐like photosensitization into a type I pathway via regulating excited‐state characteristics, w...

Shu-Xin Peng, Zi-Peng Li, Yun-Qi Kuang et al. · 0 citations
Aug 2026

Dual-triggered in situ assembly of Mn-polyphenol networks in tumor cells for enhanced manganese retention and oxidative stress amplification.

An intelligent nanoplatform is reported that unites dual TME activation with controlled in-situ coordination assembly and translates into robust in vivo antitumor effects, exemplifying a programmable strategy that enables effective regulation of metal-ion retention and release.

Mingjie Jia, Gangqiang Wang, Jing-Yi Su et al. · 0 citations

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