Introduction Podocyte injury is a critical event in the progression of chronic kidney disease (CKD), with oxidative stress as a central pathogenic mechanism. Despite the efficacy of finerenone in mitigating CKD progression, its precise cytoprotective mechanisms within podocytes remain incompletely defined. This study a...
Chen-Kai Cui, Shi-Zhuo Wei, Jian-Peng Zhang et al.· Frontiers in Pharmacology· 0 citations
Disulfidptosis is a newly recognized form of non-classical cell death, characterized by the abnormal accumulation of disulfide bonds and the collapse of the cytoskeleton. Nevertheless, the regulatory mechanisms governing this process are not fully understood. Although autophagy is a crucial cellular process necessary...
Meng-Jiao Shi, Liang-Wen Yan, Kai-Ling Hu et al.· Cell Death & Disease· 0 citations
Kuwanon E (KE) is identified as the most potent sensitizer of disulfidptosis in HCC cells and is established as a functional disulfidptosis-sensitizing agent from a natural source, providing a compelling mechanistic rationale for targeting disulfidptosis to overcome metabolic and autophagic resistance in HCC.
Xin-Yan Li, Liang-Wen Yan, Kai-Ling Hu et al.· Biochemical Pharmacology· 0 citations
This discovery fundamentally redefines the pathological role of NRF2 and positions NRF2 inhibition as a standalone, tumor-selective therapeutic strategy to eliminate Kras-driven malignancies by unleashing ferroptosis.
Dichun Huang, Mae Zhang, Ben N Stansfield et al.· Redox Biology· 0 citations
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