Author

Pengfei Li

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Aug 2026

Dual Regulation of Lipid Metabolism and Mitochondrial Respiratory Chain: The roles of Ec-GRIM19 during RGNNV Infection in orange-spotted grouper (Epinephelus coioides).

Gene associated with retinoid-interferon-induced mortality 19 (GRIM19) can affect viral infection by regulating lipid metabolism, and modulate inflammatory factors via the mitochondrial respiratory chain. However, the function of fish GRIM19s remains unclear. In this study, the GRIM19 gene (Ec-GRIM19) was identified fr...

Zhi-Tong Yu, Xiaopiao Zhong, Wenze Li et al. · Fish and Shellfish Immunolog... · 0 citations

Open access Aug 2026

Computer-aided drug screening of anti-Neobenedenia melleni drugs based on annexin B1 in farmed pearl grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus ♂)

In vivo validation of eleven compounds identified abamectin (Aba) as the most effective anti-Neobenedenia agent, achieving complete parasite elimination at 0.16 mg/L, corresponding to a therapeutic index of approximately 7.7.

Long-Kun Gao, Wei Luo, Yan-Ru Guo et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

In Vivo Screening for a Promising Antiparasitic Agent Against Neobenedenia melleni in Epinephelus fuscoguttatus♀ × E. lanceolatus♂ and Identification of Its Potential Target

Findings highlight compound D as a promising lead candidate for short-bath therapy against N. melleni and suggest that cytoskeletal disruption through β-tubulin interaction represents a plausible mechanism of action.

Long-Kun Gao, Guang-Shuo Wang, Jun-Tao Xu et al. · bioRxiv · 0 citations