MUGO (Multi-head Genomic Optimization), an in silico perturbation framework that casts variant discovery as differentiable combinatorial optimization over genomic sequence, and MUGO-prioritized variants are enriched for GWAS signals across diverse tissues and a broad spectrum of complex traits.
Si-Ying Sun, Jun-Hao Liu, Peng-Cheng Xu et al.· Proceedings of the 32nd ACM...· 0 citations
Does sperm DNA fragmentation impair blastocyst chromosomal integrity?
A high sperm DNA fragmentation index (DFI) is associated with an increased risk of blastocyst aneuploidy, particularly when the man has poor semen quality or when the female partner is aged ≥35 years.
Evidence linking sperm DFI to...
L. Lou, Peng-Cheng Xu, P. Xie et al.· Human Reproduction Open· 0 citations
Deciphering how non-coding variants perturb gene regulation is central to translating GWAS loci into mechanism, yet existing prioritization methods rarely deliver cell-type-resolved molecular effects, causal variant-to-gene attribution, or principled reasoning about combinatorial interactions. We introduce MUGO (Multi-...
Si-Ying Sun, Junhao Liu, Pengcheng Xu et al.· Proceedings of the 32nd ACM...· 0 citations
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