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Author

Peijian Chen

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Oct 2026

Oleanolic Acid Alleviates Diabetic Nephropathy by Inhibiting Ferroptosis Involving the Activation of the NRF2/HO-1 Pathway

Oleanolic acid (OA), a pentacyclic triterpenoid found in agricultural products such as grapes and olives, exhibits potential in alleviating diabetic nephropathy (DN). We validated its renoprotective effects using high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice and high glucose-stimulated HK-2 cells. Netw...

Gongyu Wu, Yu Wang, Yue Guan et al. · 0 citations
Review Open access Aug 2026

Pharmacological targeting of kidney fibrosis: druggable mechanisms, translational models, and emerging antifibrotic therapies

This review examines emerging mechanisms that govern kidney fibrogenesis, with emphasis on therapeutic tractability, and considers how experimental models can improve target prioritization and drug development, and summarizes repurposed drugs, pathway-targeted agents, receptor-directed strategies and cell-based approac...

Pei-Jian Chen, Si-Yu Xie, Ming-Lu Ding et al. · 0 citations

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