Itaconate reduces LPS/GaIN-induced hepatocyte necroptosis by inhibiting ROS-PAD4-mediated extracellular traps of macrophages.
Acute liver failure (ALF) is a critical syndrome characterized by massive hepatocyte death, yet the role of macrophage extracellular traps (METs) in its pathogenesis remains poorly defined. This study investigated the effect and mechanism of the immunometabolite itaconate on MET formation and hepatocyte necroptosis in...