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Author

Pei-Ran Lu

2 papers indexed here

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Open access Oct 2026

Single-cell variant landscape of the human mitochondrial genome reveals cell type-specific functions and disease mechanisms

Mitochondrial DNA (mtDNA) heteroplasmy is a significant source of cellular genetic diversity and can cause disease yet its distribution and functional importance across different human cell types are poorly understood. Here we present scMOCHA (Single-Cell Mitochondrial Omics for Cellular Heteroplasmy Analysis), a scala...

Chun-Jie Liu, Ting Peng, Zi-Mu Cen et al. · 0 citations
Open access Sep 2026

Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.

A novel link between mechano-transduction, 5-HT production and receptor signaling, and collagen synthesis is identified, suggesting PIEZO1, PIEZO2, and downstream 5-HT pathways as potential therapeutic targets for mitigating MR progression.

Stanley J. Stachelek, Emily J. Hauber, Xiao-Qiu Yang et al. · 0 citations

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