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Author

Pei-Lei Zhao

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Review Open access Oct 2026

Translational Challenges and Strategies for Antibody Therapeutics in Glioblastoma

Glioblastoma (GBM) remains difficult to control. Monoclonal antibodies (mAbs) have transformed the treatment of several extracranial cancers, but they have not consistently improved survival in GBM. This narrative review examines the main biological and translational barriers to antibody-based therapy. It also evaluate...

Yang Zhou, You-Ming Li, Yu Chen et al. · 0 citations
Review Open access Aug 2026

Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions

The current applications of direct neuronal reprogramming technology in several neurological diseases are discussed and the potential contamination issues in adeno-associated virus (AAV) delivery systems are highlighted and a code of conduct is proposed to avoid artifacts and pitfalls.

Yu Chen, Zhe Zheng, Pei-Lei Zhao et al. · 0 citations

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