Transcutaneous auricular vagus nerve stimulation alleviates depressive- and anxiety-like behaviors in adolescent stressed rats via SIRT1/NRF2-mediated modulation of hippocampal redox and neuroimmune homeostasis.
AIMS This study aimed to identify key molecular changes in the hippocampal subregions underlying the antidepressant effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a rat model of chronic unpredictable mild stress (CUMS) during adolescence, and to explore the potential involvement of the SIRT1/NRF...