Pei-Han Wang

Temporal Single-Nucleus Transcriptomics Defines PPARα/CPT1A-Associated Metabolic Reprogramming During Proximal Tubular Injury and Repair

Background: Metabolic reprogramming and mitochondrial dysfunction are central features of acute kidney injury (AKI), yet their temporal relationship with proximal tubular cell-state remodeling remains incompletely understood. This study aimed to characterize early metabolic alterations and proximal tubular cell-state c...

Transient tubular membrane injury is converted into persistent fibrosis through a macrophage–fibroblast relay

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

This work identifies alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC and defines an AARS1 associated metabolic and epigenetic program in BC and nominate AARS1 targeting strategies as a direction for further therapeutic development.