Author

Payel Sarkar

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Sep 2026

Efficient Myoinositol biosynthesis from glucose through gluconate bypass of glycolysis.

Microbial myo-inositol (MI) production typically requires deletion of conditionally essential genes such as phosphoglucose isomerase (pgi in E. coli) to increase pools of the precursor glucose-6-phosphate (G6P). This disrupts growth and has necessitated complex glycerol co-feeding strategies. Here, we address this limi...

Utsuki Yano, Payel Sarkar, Maximillian Golovsky et al. · Bioresource Technology · 0 citations

Jul 2026

Engineering a Gluconate Bypass Carbon Entry Architecture for Robust Stationary Phase Biomanufacturing.

Two-stage bioprocesses which decouple cell growth from product synthesis are an attractive approach to biomanufacturing. However high levels of production in stationary phase cultures often suffer from a progressive decline in metabolism. We demonstrate that in E. coli pyruvate accumulation, an inevitable consequence o...

Utsuki Yano, Payel Sarkar, M. Lynch · Metabolic Engineering · 0 citations