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Author

Payam Nahid

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Open access Sep 2026

Risk stratification for MDR/RR-TB: a comprehensive integrated patient-level analysis from TB programs and contemporary clinical trials

Tuberculosis is the deadliest infectious disease, and treatments for multidrug-resistant tuberculosis are lengthy and toxic. By analyzing a large international database (N = 7,750), we identified patient risk phenotypes linked to unfavorable outcomes. Factors like HIV infection, age, low BMI, smoking, acid-fast bac...

M. García-Cremades, Jonathon R. Campbell, N. Strydom et al. · 0 citations
Open access Sep 2026

Ethambutol Population Pharmacokinetics and Pharmacodynamics from a Phase 3 Confirmatory Trial for the Treatment of Tuberculosis

Background: Ethambutol, a longstanding treatment for tuberculosis, lacks comprehensive pharmacokinetic data, particularly regarding covariates affecting exposure and their link to treatment outcomes. Using the largest data to date from Study 31/AIDS Clinical Trials Group A5349, we aimed to characterize ethambutol pharm...

S. Alkhafaji, E. Yang, Kaylee Lee et al. · 0 citations

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