Novel 1,3,5-triazine-based TRPA1 activators alleviate pro-fibrotic response in human lung fibroblasts.
Airway remodeling (AR) is a hallmark of chronic respiratory diseases (CRDs) and involves progressive structural alterations of the airway wall, leading to thickening and narrowing. Multiple cell types contribute to AR, including lung fibroblasts, which - under the influence of transforming growth factor (TGF-β) - upreg...