Pavan Reddy Regatti

Ultra-compact amyloidogenic fusion tags mediated efficient production of liraglutide precursors and molecular insights

The recombinant production of therapeutic peptides such as the glucagon-like peptide-1 (GLP-1) analogue liraglutide precursor in E. coli is often constrained by peptide instability, susceptibility to intracellular proteolysis, and the use of large fusion partners that reduce the target peptide mass fraction and i...