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Author

Paulina Dragan

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2 papers indexed here

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Sep 2026

C5aR2 signaling mechanisms via the β-arrestin-dependent pathway observed in microsecond-scale molecular dynamics simulations.

The complement system primarily regulates innate immunity, contributing to nonspecific antipathogen defense, and is linked to adaptive immunity. One of its components, C5 convertase, initiates the last stage of the complement cascade, leading to the cleavage of C5 into C5a and C5b and the formation of the membrane atta...

Paulina Dragan, Dorota Latek · 1 citation
Open access Sep 2026

Microswitch-Guided Sampling for the Detection of Ligand Signaling Bias in GPCR Systems

Biased signaling occurs when a ligand preferentially activates a specific signaling pathway at a certain receptor within a particular cellular environment. As pharmaceuticals, functionally selective (biased) compounds can engage beneficial signaling pathways while avoiding those linked to adverse effects, resulting in...

Paulina Dragan, Dorota Latek · 0 citations

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