Author

Paul C Whitford

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Open access Mar 2025

Nucleosome Engagement Regulates RORγt Structure and Dynamics

RORγt is a key transcriptional regulator that supports protective pathogen clearance but also drives autoimmune disorders. Genetic studies have identified RORγt mutations that selectively protect from autoimmunity without compromising host defense. Herein, we describe the molecular principles governing how RORγt select...

Timothy S. Strutzenberg, Xian-Du Li, Matthew D. Mann et al. · bioRxiv · 0 citations

Open access Oct 2026

Molecular sterics guide tmRNA translocation on the ribosome

Translation of defective mRNA transcripts can lead to the formation of stalled “non-stop” ribosome complexes. To rescue these ribosomes, bacteria have evolved a mechanism called trans-translation that is mediated by transfer-messenger RNA (tmRNA) and small protein B (SmpB). During the translocation step of trans-transl...

George Wanes, K. Keiler, Christine M. Dunham et al. · bioRxiv · 0 citations

Open access Aug 2026

Ribosomal protein bL27 protects translating ribosomes from tmRNA-SmpB

Trans-translation and bL27 data are linked and support a model in which the amino terminus of bL27 acts as a gatekeeper to prevent tmRNA from sterically interfering with tRNA (transfer RNA) on the ribosome.

Divyasorubini Seerpatham, George Wanes, Chathuri Pathirage et al. · Science Advances · 0 citations