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Author

Patrick R. Griffin

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Open access Mar 2025

Nucleosome Engagement Regulates RORγt Structure and Dynamics

RORγt is a key transcriptional regulator that supports protective pathogen clearance but also drives autoimmune disorders. Genetic studies have identified RORγt mutations that selectively protect from autoimmunity without compromising host defense. Herein, we describe the molecular principles governing how RORγt select...

Timothy S. Strutzenberg, Xian-Du Li, Matthew D. Mann et al. · 0 citations
Jul 2026

Mapping REV-ERBα’s Protein-Protein Interactions to Understand TH17 Cell Regulation and Inflammation 2258028

These efforts aim to bolster the understanding of the REV-ERBs, nuclear receptor biology, and TH17 pathogenesis–all of which may inform the development of focused therapeutics for treatment of autoimmune and chronic inflammatory diseases.

Bin-Bin Schell, S. Mosure, Timothy R. O’Leary et al. · 0 citations
Open access Jul 2026

Rational design of RORγT small molecule modulators results in tunable LXRα pleiotropic effects in Th17 cells 2267479

Rational design of small molecule modulators enhanced RORγT inverse agonism and tuned LXRα agonism enhanced RORγT inverse agonism and tuned LXRα agonism better suppressed the pathogenic Th17 phenotype, reducing IL-17 secretion and downstream gene expression.

Matthew D. Mann, Mi-Ra Chang, Vuong Q. Dang et al. · 0 citations

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