Open access
Jul 2026
Tumor-derived Ilp8 and Upd3 contribute to intestinal progenitor cells depletion during cachexia in Drosophila larvae.
It is described here that neoplastic tumors also affect the development of the larval midgut, leading to altered cell-type numbers, with a depletion of the stem-cell-like adult midgut precursors (AMPs), and a disorganization of the niche cells which enter precocious differentiation.
Jennifer Falconi, Miriam Rodríguez-Vázquez, Katrin Strobel et al.
· Cell Reports · 0 citations