Open access
Aug 2026
Microtubule Lattice Spacing Governs MAP-Motor Regulation
It is found that kinesin-1 is largely insensitive to tubulin PTMs but is strongly regulated by MT lattice spacing, which supports a two-layer transport code in which MT lattice spacing directs MAP binding, and MAPs determine which motors can move along individual MT tracks.
Jonathan Fernandes, Joseph Slivka, Aryan Taheri et al.
· bioRxiv · 0 citations