Synthesis of Large- and Medium-Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr.
We report the first examples of catalytic, intramolecular N-heterocycle arylation by nucleophilic aromatic substitution (SNAr), a general method for synthesis of highly strained macrocycles and medium-sized heterobiaryl atropisomeric rings. Key to the approach is the ability to generate a strong base catalytically, as...