We describe a sequential protocol for iridium(III)-catalyzed o-C-H (E)-allylation of 2-aryl quinazolinones with vinylcyclopropanes (VCPs), followed by palladium(II)-catalyzed aza-Wacker cyclization and subsequent olefin migration, affording piperidine-fused quinazolinones. A broad substrate scope and complete site sele...
Anand Kumar, HaeIn Kim, Chaeeun Kim et al.· Journal of Organic Chemistry· 0 citations
GPR119 is a compelling therapeutic target for type 2 diabetes due to its role in promoting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucose-dependent insulin secretion. This study aimed to develop a series of novel GPR119 agonists with exceptional kinetic solubility over a...
Jaeki Min, Jihun Kim, Kyeongwon Moon et al.· Journal of Medicinal Chemist...· 0 citations
Compound 13e exhibited potent antiviral efficacy, as evidenced by viremia quantification and histopathological analysis results, without causing significant body weight loss or other toxicities.
Dabeen Lim, Chanwoo Lee, Jihun Kim et al.· Bioorganic chemistry (Print)· 0 citations
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