Proton Sponge-Enabled Dual-Driven Nanomotors for MRI-Guided Tumor-Penetrating Synergistic Therapy of Pancreatic Cancer.
Dense stromal barriers and lysosomal sequestration severely restrict the extracellular transport and intracellular trafficking of nanomedicines in pancreatic cancer, while the robust glutathione (GSH)-dependent antioxidant defense further compromises therapeutic efficacy. Here, we developed a proton sponge-enabled dual...